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Long-acting agents, on the other hand, provide continuous receptor activation due to structural modifications that slow their absorption, reduce the rate of renal clearance or extend their half-lives [52, 53]

Oral bioavailability is significantly lower than injection, requiring much higher doses to achieve comparable GH release

This elevated activity can deplete NAD+ levels, slow down metabolism, and contribute to the storage of fat

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Efficacy of melatonin as a sleep-promoting agent

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