A B12 deficiency can cause demyelination, leading to neuropathy with neurological signs like numbness, pins and needles, and muscle weakness, especially in the feet and hands
Int J Dev Neurosci
As B12 is essential for the production of red blood cells and proper nervous system function, its deficiency can disrupt these processes and lead to symptoms like gastrointestinal discomfort and poor appetite, which may contribute to unintended weight loss
This reaction is catalyzed by the enzyme methionine synthase with B 12 as an essential cofactor
Treatment of Leber's optic atrophy
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