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The review also described TB4s ability to decrease the number of myofibroblasts in wounds, resulting in decreased scar formation and fibrosis
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In experimental models, these peptides are studied together for their potential roles in cell migration, extracellular matrix remodeling, and skin and connective-tissue signaling processes
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This is in turn converted to 5 S ,6 S -epoxy-15 R -hydroxy-ETE, as described above for lipoxins, by the action of the 5lipoxygenase in leukocytes and thence to epi-lipoxins, i.e., epi-LXA 4 (5 S ,6 S ,15 S -trihydroxy-7 E ,9 E ,11 Z ,13 E -eicosatetraenoic acid) and epi-LXB 4 (5 S ,14 R ,15 R -trihydroxy-6 E ,8 Z ,10 E ,12 E -eicosatetraenoic acid), the latter with 15 R stereochemistry
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