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B12 injections are water-soluble and any excess is typically excreted through urine, making overdoses rare

Rotate injection sites: To prevent tissue irritation, researchers may vary the injection locations, typically including the thigh, upper arm, and abdomen

Researchers might accept a degree of variability for the sake of convenience

MOTS-c also influences the folate cycle through AICAR accumulation [2], raising an unresolved question about interaction with methotrexate or other antifolate medications

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As B12 helps make red blood cells, a lack of vitamin B12 can cause anemia