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While nuclear factor erythroid 2-related factor 2 (NRF2) and CCAAT/Enhancer Binding Protein (CEBP) also contribute to a minor increase in CHAC1 transcription, their roles are less pronounced compared to ATF4 ( FIGURE 4 ATF4 and ATF3 regulate CHAC1 expression by binding to specific sites within its promoter, the ATF/cAMP response element (CRE) at position 267 and the ATF/CRE modifier (ACM) motif at 248

doi: 10.1007/s11524-018-00341-1 127

Under homeostatic conditions, DCs rely on oxidative phosphorylation (OxPhos) and fatty acid oxidation (FAO), whereas inflammation drives a shift in their metabolism toward aerobic glycolysis, which is vital for initiating inflammatory responses (135)

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Ferroptosis of tumour neutrophils causes immune suppression in cancer