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Characterized by: Neurological dysfunction including: Headache Visual disturbances Confusion Aphasia Transient paresis Weakness Seizures Fever Abdominal pain Bleeding Features that should prompt consideration of TTP as the cause of TMA in a pregnant woman include: Presentation prior to 20 weeks Severe neurologic symptoms Cardiac injury Treatment is with plasma exchange, typically started based on high suspicion of the diagnosis while the ADAMTS13 levels are pending
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10.4081/itjm.2019.1192 Ital J Med
Efforts to pinpoint other responsible targets by examining related kinases like DYRK1B, DYRK2, DYRK3, DYRK4, the CLK family, the DREAM complex, and NFAT proteins were unsuccessful, as silencing these did not replicate the differentiation effects (Ackeifi et al
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