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For example, people with pernicious anemia might need different doses because they cant make the right proteins
Alternative GLP-1 formulations, dose adjustments, or additional supportive medications may improve tolerability whilst maintaining the metabolic benefits of therapy
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once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial
As ionic strength increases (adding salts), this repulsion is shielded, which in some cases can lead to increased aggregation or precipitation of the peptide (especially if the peptide has hydrophobic patches)
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