Drugs like the GLP-1s Wegovy and Saxenda are FDA-approved for long-term use, which makes sense because they treat a long-term conditionobesity
March 22, 2023
Suitable for advanced in-vitro studies on receptor pharmacology and metabolic signal transduction
Research in humans is a bit less impressive Clinical trials in humans A 1981 double-blind study found that chronic insomniac patients found that subjects slept 59% more, shorter sleep latency, and higher sleep efficiency (Schneider 1981) A 1987 double-blind study did not find any statistically significant changes in sleep structure as measured by REM sleep, NREM sleep, or total sleep time (Debellis 1987) A 1992 double-blind study in 14 chronic insomnia patients found higher sleep efficiency and subjectively estimated tiredness decreased to similar levels of healthy subjects in 7 nights of injections (Schneider 1992) There are some limitations to these studies however
Gradually, as healing progresses over weeks, the pain typically subsides and improvements become evident
This reduces the appearance of fine lines, improves skin firmness, and protects skin from environmental ageing factors
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