demonstrated in a dose-escalation trial (N=56 healthy subjects aged 21, 49) that a single subcutaneous injection of CJC-1295 DAC raised mean IGF-1 levels by 1.5- to 3-fold and sustained GH elevation for up to 8 days [1]
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Participants were genotyped using the Illumina Global Screening Array v.1.0, v.2.0 and v.2.0_EST
many of these drugs are also approved in other countries, but may have different indications and costs
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56 Taken together, it is clear that GIPR signalling affects bone turnover, but the overall significance of these effects need to be fully determined