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Precise dose-escalation protocols remain necessary to manage gastrointestinal side effects and maintain treatment compliance

[1] Jastreboff, A

Although direct evidence of trained immunity in clinical AD is still limited, transcriptional, epigenetic, and metabolic alterations observed in immune cells, including microglia, monocytes, and dendritic cells, from both patients and animal models are consistent with mechanisms underlying innate immune memory

da Silva LE, de Oliveira MP, da Silva MR, Abel Jda, Tartari S, de Costa G et al

16 weeks 4 vials 16 full weekly maintenance doses

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