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TRIUMPH-4, a separate trial in people with obesity and knee osteoarthritis, an older and more medically complex group, showed 28.7 percent weight loss at 68 weeks but a higher rate of people stopping treatment due to side effects, at 18.2 percent, compared with 11.3 percent in the TRIUMPH-1 group

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The trial did not randomize all 902 run-in entrants

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Intranasal corticosteroid sprays, second-generation antihistamines, and non-drug approaches can provide meaningful symptom relief without compromising blood pressure control

Start with manageable amounts and gradually increase intensity as tolerated, ensuring you maintain adequate nutrition and hydration to support your activity level