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Moreover, inhibiting CalcR-expressing NTS neurons increases food intake and partially prevents the appetite-suppressing effects of exendin-4, while their silencing leads to weight gain on a high-fat diet [61, 63]

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Avoiding hydrogenated oils to reduce dietary trans fat Reducing added sugar and sodium Limiting daily alcohol consumption to no more than one drink for women and two drinks for men In controlled clinical trials that replaced dietary saturated fat with polyunsaturated vegetable oils such as those listed above, cardiovascular disease was reduced by about 30%, which is roughly the degree of protection conferred by statin drugs