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Patients were to be randomized to 1200 mg, 450 mg, or placebo, administered intravenously daily for 3 days followed by weekly for 4 weeks

Ethics declarations Ethics approval and consent to participate All experiments with brain organoids were performed in accordance with the national and international ethics guidelines, and were approved by the ethics committee at the University of Luxembourg, Comit National dEthique de Recherche (CNER

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Analysis of calcium ion (Ca 2+ ) levels in macrophages To detect the intracellular Ca 2+ content, 143B cells were incubated with PBS, Ru(II)-OH, NP2, and NP4 (Ru 10 M) for 6 h

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A published gene expression study reported that GHK-Cu modulates the expression of over 4,000 human genes, including those involved in tissue remodelling and antioxidant defence