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They follow strict diets and exercise regimens but still find it nearly impossible to lose weight

Since VTA GABA neurons in the VTA have also been shown to be outwardly projecting, it is also possible that GLP-1Rs are expressed on GABA neurons in the VTA that project to downstream nuclei including the NAc, CeA, prefrontal cortex, lateral hypothalamus, and the lateral habenula 68,69,70

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Oral GLP-1 pill delivers nearly 12 percent weight loss in 36 weeks, study finds (NewsNation) Patients taking the oral GLP-1 drug aleniglipron saw up to a 12 percent reduction in body weight after 36 weeks, according to researchers