May Affect Pain Perception: GHRP-2 exhibits action at opioid receptors, indicating its potential impact on pain perception
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The trial enrolled 445 adults with obesity and moderate-to-severe knee osteoarthritis pain (without diabetes), randomized 1:1:1 to 9mg, 12mg, or placebo over 68 weeks
Natural products, particularly probiotics and antioxidants, appear to exert protective effects by stabilizing Nrf2 (175), thereby enhancing the expression of endogenous antioxidant enzymes such as superoxide dismutase (SOD), catalase, and glutathione peroxidase (176)