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While singly-housed animals may experience stress that impacts metabolism, body weight, and adiposity 65,66,67,68,69 , the singly-housed animals in this study were treated identically (to the best of the experimenters ability) to minimize and equalize stress across all animals and reduce confounding variables

Some long-term users cycle three months at maintenance concentration followed by one month at elevated concentration for periodic intensive phases

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It doesnt have to be congruent