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Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008

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In a 2-year CV outcomes trial with semaglutide injection involving patients with type 2 diabetes mellitus and high CV risk, diabetic retinopathy complications (which was a 4-component adjudicated endpoint) occurred in patients treated with semaglutide injection (3%) compared to placebo (1.8%)

Additionally, systemic administration of VIP can lead to cardiovascular and gastrointestinal side effects, such as a significant decrease in blood pressure (7)

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