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Based on the identification of CDK4 amplification and homologous recombination repair deficiency as prominent features of osteosarcoma, a MOF co-loaded with CDK4/6 inhibitors and PARP inhibitors was designed and coated with a bio-membrane targeting B7H3
Proc Nutr Soc 78:3444 Schomburg L, Kohrle J (2008) On the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health
While this purification is conceptually very similar to many other types of affinity purifications, there are a few specific things to keep in mind when purifying GST-fusion proteins
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