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In the LEAD-5 trial, liraglutide (1.8 mg once daily) reduced HbA1c more than insulin glargine during the treatment period (26 weeks) [31]

Fibre is fermented by gut bacteria into short-chain fatty acids, which activate other receptors (FFAR2 and FFAR3) that also trigger GLP-1 release

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The 56-week COR-I trial studied the use of Contrave in patients with a BMI of 27 or higher and found that participants taking a combination of naltrexone and bupropion lost an average of 4.8% more weight than those given a placebo

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