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In two in vitro BBB models, these dendriplexes successfully crossed the BBB, decreased GLS1 expression and altered the exometabolome of GBM cell lines, concomitantly with autophagy activation
doi: 10.3892/ol.2018.9619 67 HanadaK.UchidaT.TsukamotoY.WatadaM.YamaguchiN.YamamotoK.et al
This finding aligns with current AAFP clinical guidance recommending oral therapy as a first-line option for most patients
[5] [9] Zepbound was subsequently approved in November 2023 for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity such as hypertension, dyslipidemia, or obstructive sleep apnea
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