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In addition, in RP conditions the redox system is disturbed and as such for all postnatal days the [GSH]/[GSSG] ratio is sensitive to elements that govern the enzymatic reaction in which GSH reduces ROS

To demonstrate that suppression of p70S6K protein and pNPM1 by RSL3 is GPX4 inhibition-specific in PTC cells, we treated K1 cells with RSL3 (3 M) in the presence of ferrostatin-1 (5 M), an effective inhibitor of ferroptosis and analyzed by Western blotting

PMID: 39286770 5 A Study of Maternal Patients Diagnosed with Inborn Errors of Metabolism Due to Positive Newborn Mass Screening in Their Newborns

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