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Clinical trial data for FDA-approved branded semaglutide showed meaningful weight changes beginning in weeks 4 through 12, with continued results accumulating over a 68-week period
In conclusion, treatment with once-weekly subcutaneous semaglutide in conjunction with behavioral intervention in adults with overweight (with at least one weight-related comorbidity) or obesity (without diabetes) was associated with clinically impactful and sustained weight loss of 15.2% at week 104, along with improvements in weight-related cardiometabolic risk factors
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Among those who stayed on treatment for the full 68 weeks, cagrilintide 2.4 mg delivered an average of about 12% body weight reduction , compared to 2.3% for placebo
doi: 10.1038/mp.2012.77 107 OgbonnayaESClarkeGShanahanFDinanTGCryanJFOlearyOF
