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While it is known that B-vitamin supplementation effectively treats hyperhomocysteinemia, there is a need for well-designed, large trials to evaluate the effect of B-vitamin supplementation on long-term outcomes, such as age-related cognitive decline and the incidence of Alzheimers disease

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The B12 used here is cyanocobalamin, the most common supplement form

You can also get vitamin B12 by consuming fortified cereals, plant-based milks, and nutritional yeast

Safety and Tolerability of the Hexadecapeptide AOD 9604 in Humans. Journal of Endocrinology & Metabolism , 2013

Individuals with certain health conditions, such as Lebers disease (a rare inherited eye disease), should avoid B12 supplements as it can worsen the condition