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Moreover, there is a need for additional studies that identify patients or sub-types of patients with various addictions who might benefit from treatment with such medications: for instance, the possibility that polymorphisms in the GLP-1R genes influence the treatment outcome of GLP-1R agonists on alcohol drinking in patients with AUD

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Additionally, more compounds make it harder to isolate which one is responsible for any observed benefit (or harm)

AHK-Cu is structurally related to other copper peptide systems, but differs by its alanine-histidine-lysine sequence, which may contribute to distinct receptor interactions and experimental behavior compared with glycine-based copper tripeptides