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Animal models have demonstrated that GLP-1 RAs reduce drug-seeking behavior and attenuate conditioned place preference for substances such as alcohol, nicotine, and cocaine (32)

The Saxagliptin Assessment of Vascular Outcomes (SAVOR-TIMI 53) study is a similar study in 12,000 patients comparing saxagliptin with placebo in diabetic patients with high cardiovascular risk

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Data are unavailable on the toxicity of other preservatives in this age group