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Decision Guidance Choose cagrilintide + tirzepatide when you want the strongest single-agent base (tirzepatide is FDA-approved and outperforms semaglutide head-to-head) plus amylin layering
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Modified melasma area and severity index (MASI) score was calculated before and after therapy
Clinical trials have demonstrated substantial improvements in hemoglobin A1c reduction (up to 2.5% decrease) in diabetes patients, while weight loss of up to 20% was observed primarily in adults with obesity without diabetes in the SURMOUNT-1 trial
Eligibility was also dependent on first prescription of the GLP-1 RA of interest (either as monotherapy or part of combined therapy) during the selection window
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