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Consistently, NTAPP increased genes activating Wnt signaling pathway, which is involved in AMER3 17 , FRZB 18 , RSPO2 19 , LRP5L 20 , GRK5 21 , WNT11 22,23 and TMEM198 24 (Supplementary Figure 3d)

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After application, GHK-Cu is absorbed into the upper layers of the skin where it interacts with skin cells and biological pathways involved in skin maintenance

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It does not cause dependence, as do drugs such as benzodiazepines