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After virus entry in the CNS, it infects and replicates in microglia that acquire inflammatory phenotype, inducing a neurological damages [7]

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The clearance of senescent liver cells triggered by DMC is synergistically mediated by the activation of ferritinophagy and the inhibition of ferrochelatase (FECH), an essential enzyme for heme biosynthesis by inserting a ferrous ion into protoporphyrin IX (134)

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Additionally, exercise is an important measure to delay myocyte aging, and moderate exercise training can improve myocyte function and delay age-related pathological changes in the heart [114]

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