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For structural comparison, the dual GIP/GLP-1 agonist tirzepatide is lipidated at position 20, while the GLP-1 mono-agonist semaglutide is lipidated at position 26
Quick Hits Multi-vitamins reduce aging afterall A randomized controlled trial with 3,500+ participants showed taking a daily multivitamin improved memory and cognitive performance in older adultsroughly equivalent to reversing ~3 years of age-related memory decline
PMID: 40348320 Hypertens Res2026 Apr 10
MT-IIs anti-inflammatory properties likely stem from its action on melanocortin receptors (particularly MC1R and MC3R) that are expressed on immune cells, including macrophages and dendritic cells
Meanwhile, combining the best of lifestyle choices with informed medical care remains the strongest strategy
Campbell JE, Mller TD, Finan B, DiMarchi RD, Tschp MH, DAlessio DA
