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The microbiota modulates GLP-1 secretion through microbial metabolites
Adjunctive basal GLP-1-RA therapy in patients after MBS may be a promising treatment choice in weight management in addition to lifestyle changes, not only due to increased GLP-1 signaling, but also to a putative blunting effect on metabolic adaptation that occurs after MBS, increased fat oxidation, and decreased carbohydrate and protein oxidation
Or worse, you underdose for weeks and wonder why nothing is happening
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