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Its most prominent function has been suggested to regulate apoptosis in senescent cells

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It is also researched in the context of circadian rhythm signaling and peptidergic neurotransmission in cellular and animal study models

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Indeed, lithium therapy of cultured cerebellar granule cells increased mRNA and protein levels of Bcl-2, and the Bcl-2/Bax protein level ratio increased by 5-fold after treatment duration for 57 days 124

1 2 3 4 Bertilsson G, Patrone C, Zachrisson O, Andersson A, Dannaeus K, Heidrich J, Kortesmaa J, Mercer A, Nielsen E, Rnnholm H, Wikstrm L (February 2008)