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That study used synthetic, non-bioidentical hormones in older women well past menopause a very different profile from the patients we treat
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But the conditions that produced this outcome were visible years before the crisis through generic market concentration data: products with fewer than four manufacturers, with API sourced from a small number of facilities, manufactured on thin margins without buffer stock, are structurally vulnerable
![Physiologic effects of GLP-1 (adapted from Granata et al. [11])](https://www.researchgate.net/publication/359199250/figure/fig1/AS:11431281081130351@1661532031197/Physiologic-effects-of-GLP-1-adapted-from-Granata-et-al-11.png)