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The FDAs totality of evidence standard for biosimilarity requires the applicant to demonstrate analytical similarity, and for complex bio-betters the analytical similarity demonstration is itself a substantial technical undertaking
Tirzepatide is a dual agonist of both GLP-1 and GIP, while semaglutide is only a GLP-1 agonist
Week 0: final tirzepatide dose
Drugs like Ozempic and Wegovy have a very long half-life (the time it takes for the body to eliminate half of the drug) [12]
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