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The bottom line GLP-1 drugs are not a replacement for insulin, and they are not officially approved for T1D (outside of the new 2026 ADA recommendation for T1D with obesity)
Appetite Suppression (Central Nervous System) GLP-1 RAs can cross the blood-brain barrier or act on circumventricular organs to target specific brain regions, including the hypothalamus, hindbrain, and mesolimbic reward system (Zheng et al., 2024)
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Estrogens play a pivotal role in the adult and developing brain (Morissette et al., 2008), exerting neuroprotective effects under homeostatic and pathologic conditions
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