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The GLP-1 fatigue guide and the GLP-1 headache guide provide broader context for these side effects across the entire class of incretin-based therapies, not just tirzepatide specifically

Some clients experience a mild tenderness in the injection area, but this usually subsides quickly

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If you are new to GLP-1 medications, or if you have not taken one in some time, you will begin at Tier 1

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For Lebers optic atrophy or smokers blindness, the usual dose starts at 1000mcg, given daily for 2 weeks, followed by twice weekly