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Ile 12 Using cryo-electron microscopy, Zhang et al found that a cluster of neighboring serines (Ser 14 , Ser 17 , and Ser 18 of GLP-1) form polar interactions with Thr 298 , the backbone oxygen of Trp 297 , and the nitrogen of Arg 299 in GLP-1R

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This is particularly important for B-vitamin preparations, which can cause anaphylactic reactions in sensitized individuals

Peptide purity directly impacts the validity of research outcomes