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Safety monitoring should account for several important risks: Diabetic retinopathy : Patients with existing retinopathy should be monitored closely, particularly if experiencing rapid improvements in blood glucose levels, as this can temporarily worsen eye complications

Determination of inflammatory markers To evaluate neuroinflammation in brain tissue treated with TMX and/or LC, proinflammatory markers such as tumor necrosis factor- (TNF-), interleukin-6 (IL-6), interleukin-1 (IL-1), and nuclear factor kappa B (NF-B) were measured by enzyme-linked immunosorbent assay (ELISA) kits obtained from ABclonal and Biosourse (USA), respectively, according to the manufacturers instructions for TNF- (ABclonal, cat no

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In addition, it reduced both MDA and NO production in the liver and kidney