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We focus on their latent applications in conditions including psoriasis, inflammatory bowel disease (IBD), rheumatoid arthritis (RA), asthma, multiple sclerosis (MS), Sjgrens syndrome (SS), and systemic lupus erythematosus (SLE), highlighting the broader therapeutic benefits of GLP-1RAs beyond their well-established use in managing T2DM and obesity

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doi:10.1016/S0014-2999(96)00795-9 42

As shown in Table 1 [1,8,12-19] , because of the critical role of this pathway in energy regulation, functional abnormalities caused by mutations in any of its critical genes (e.g., LEP , LEPR , POMC , PCSK1 , MC4R ) can lead to severe early-onset obesity and extreme hyperphagia and are often accompanied by endocrine abnormalities due to deficiencies in related hormones, such as hypogonadism and hypothyroidism [12,20]

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