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In most major obesity trials, GLP-1 therapy was: Escalated to high or maximum tolerated doses Stopped abruptly, not down-titrated Followed by little or no continuation of structured lifestyle support In the STEP-1 extension trial (semaglutide 2.4 mg), participants who discontinued therapy regained approximately two-thirds of their prior weight loss over the following year
95% CI 0.83 to 0.94)
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This overabundance of free radicals is a major contributor to many diseases, including heart disease and cancer, and it also plays a significant role in age-related changes and illnesses
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