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Additionally, a randomized, double-blind, placebo-controlled trial in 162 elderly people (70 years) with mild vitamin B 12 deficiency found that vitamin B 12 supplementation for 24 weeks, alone or in combination with folic acid, did not improve memory performance (117)

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In addition to allosteric activation of G6PDH, the G6PD gene is transcriptionally activated in response to oxidative stress

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