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Meta-analyses including over 40,000 individuals demonstrate a decreased risk of composite renal outcomes (HR 0.79, 95% CI 0.720.87), confirming renal protection as a class effect independent of cardiovascular advantages (Mavrakanas et al

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Related studies have found that GLP-1RAs could limit the growth of prostate cancer by inhibiting the PI3K/AKT/mTOR and ERK/MAPK pathways, while could also limit the growth of pancreatic and prostate cancer cells by inhibiting the NF-kB pathway (210212)

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