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Key findings from the evidence base include: Depression is not listed among the common adverse effects (occurring in 1/100 patients) in the UK Summary of Product Characteristics (SmPC) for Mounjaro Psychiatric adverse events were monitored but did not emerge as safety signals during phase 3 trials The most frequently reported side effects remain gastrointestinal (nausea, diarrhoea, vomiting, constipation) No mechanistic pathway has been established linking GIP/GLP-1 receptor agonism directly to depressive symptoms However, post-marketing surveillance continues to be crucial