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Shared side effects both medications can cause: Nausea (most common, especially when starting) Vomiting Diarrhea or constipation Stomach discomfort Loss of appetite Headache Dizziness Semaglutide-specific notes: Side effects are generally mild to moderate, and they often decrease as your body adjusts over the first few weeks

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10.1016/j.jpsychires.2015.01.003 36 MertensI

Western blot and qRT-PCR were used to determine the changes in ferroptosis marker gene expression

Contact your doctor immediately if you experience: Severe, persistent abdominal pain that may indicate pancreatitis, particularly if radiating to the back or accompanied by vomiting Signs of gallbladder disease , including right upper quadrant pain, fever, jaundice, or clay-colored stools (cholelithiasis rates in clinical trials range from approximately 0.6% to 2.5%, depending on dose and duration) Symptoms of acute kidney injury , such as decreased urination, swelling, fatigue, or confusion, especially if accompanied by dehydration Visual changes , including blurred vision or difficulty focusing, which may indicate diabetic retinopathy complications (rapid glycemic improvement with tirzepatide can temporarily worsen retinopathy) Severe allergic reactions , including rash, itching, swelling of face or throat, severe dizziness, or difficulty breathing Persistent vomiting or diarrhea lasting more than 24 hours, which increases dehydration and acute kidney injury risk Symptoms suggesting thyroid tumors , including neck mass, hoarseness, dysphagia, or dyspnea New or worsening depression, suicidal thoughts, or unusual changes in mood or behavior , particularly in patients taking Zepbound for weight management Routine monitoring should include periodic assessment of renal function, particularly in patients with pre-existing kidney disease or those experiencing significant gastrointestinal symptoms