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Biochemical markers (e.g

This review noted that ipamorelin was one of a number of GHS that can significantly improve body composition while ameliorating specific hypogonadal symptoms including fat gain and muscular atrophy [5]

Selective Stimulation : Increases GH levels with minimal effect on ACTH, cortisol, or prolactin, making it one of the cleanest GH-releasing peptides

patients with symptomatic decline (poor sleep, body composition changes, reduced energy) may be candidates Patients with body composition goals where GH optimization is clinically relevant: body fat accumulation alongside lean mass reduction that has not responded adequately to lifestyle intervention Individuals seeking sleep quality improvement where GH-axis optimization is part of the clinical picture Athletes or active individuals with recovery requirements where GH-mediated protein synthesis is a clinical priority Patients already in a comprehensive longevity program where GH-axis assessment and optimization is part of the protocol The decision to prescribe Ipamorelin or any GH secretagogue begins with a clinical assessment that includes baseline IGF-1 measurement (the primary marker of GH axis activity), review of the patient's symptom profile, and evaluation of contraindications

Wang KL, Yang Q, Cleary KR, Swisher SG , Correa AM, Komaki R, Ajani JA, Rashid A, Hamilton SR, Wu TT

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