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In addition, more lipophilic drugs will tend to pass not only through the BBB, but also to other organs, which consequently results in a reduced availability of drugs to enter the brain (27)
The dogs were divided into 3 groups depending on the received dose, including the following 3 doses: 0 mg/day 236 mg/d 492 mg/d Each group was further divided into two subgroups, receiving either 110% or 120% of their Maintenance Energy Requirement (MER), which was evaluated in a metabolic chamber at baseline
P.BrandonC
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