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It can also develop from poor B12 absorption, because some people are not able to absorb it well

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Although the biological activity of CD20 and CD80 are not fully elucidated, CD20 allows specific and effective B-cell depletion and CD80 involves in T cell costimulation (141)

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Less common reactions include contact dermatitis (a rash or itching that doesnt resolve), persistent redness, or a localized copper reaction