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It is worth noting that SGLT2 inhibitors not only enhance glycemic control but also reduce hypertension and mitigate MetS in animal models co-administered with furosemide or hydrochlorothiazide (Rahman et al., 2016), as well as in clinical settings involving patients with chronic heart failure (Grodin and Tang, 2020

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The result is even more pronounced weight loss

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Any dose adjustments need to be undertaken on an individualised basis considering individual patient considerations, HbA1c target, hypoglycaemic awareness and medication regimen[511]