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The majority of the studies (see above in red) are preclinical studies in rodents, the vast majority of which have been done by a single research group in Croatia, which has been rinsing and repeating the same approach for decades

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Its also used in joint health supplements due to its potential anti-inflammatory properties, helping to protect cartilage in conditions like osteoarthritis

376 Platelet-derived MMP-2 is also essential in the initiation of atherogenesis by activating endothelial PAR1, triggering endothelial p38/MAPK signaling, and inducing the expression of adhesion molecules like P-selectin