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A 2014 publication (McCoy et al., Journal of Pharmacology and Experimental Therapeutics) was retracted due to concerns about data fabrication

You can check out this dosage chart to see how tirzepatide stacks up against other medications

Reports of temporary tiredness or mild headaches when first starting have been reported

Patients experiencing symptoms such as rapid onset of widespread itching, facial swelling, breathing difficulties, dizziness, or collapse should call 999 or attend the nearest Accident & Emergency department without delay

While the occurrence is low, this highlights the importance of monitoring and early intervention, especially in individuals with pre-existing conditions that may predispose them to pancreatitis, such as gallstones, high triglycerides, chronic alcohol use and obesity