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The mean percentage change in body weight at week 68 was 14.9% in the semaglutide group vs 2.4% with placebo, for an estimated treatment difference of 12.4 percentage points (95% CI, 13.4 to 11.5)

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Early signs include tingling or 'pins and needles' in the feet and hands, numbness in the extremities, burning pain (often worse at night), balance problems, and muscle weakness

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And anyone with a history of eating disorders or extreme restriction may find that this diet triggers unhealthy patterns

Some studies , conducted on mice, showed that semaglutide crossing the blood-brain barrier might increase the ventral tegmental area (VTA) dopamine neuron activity, thus reducing appetite and cravings for other activities like drinking